Neonates Support Lymphopenia-Induced Proliferation

Lymphopenia-Induced T Cell Proliferation Innate Immune Cell CD45 Regulates

Mathematical modeling reveals the biological program regulating lymphopenia-induced proliferation.

Recognition of peptide-MHC by the TCR induces T lymphocytes to undergo cell division. Although recognition of foreign peptide induces a program of cellular division and differentiation by responding T cells, stimulation by self-peptide MHC complexes in lymphopenic conditions induces a slower burst of divisions that may or may not be accompanied by effector differentiation. Although both respons...

PD-1 Controls Tonic Signaling and Lymphopenia-Induced Proliferation of T Lymphocytes

Recovery of the T lymphocyte compartment within a lymphopenic host by lymphopenia-induced proliferation (LIP) is regulated by inter- and intraclonal competition for limited resources, including homeostatic cytokines and peptide:MHC (pMHC) complexes with which the TCR can interact at least weakly to yield a tonic signal. Importantly, the process of LIP can synergize with other factors that promo...

T cell activation and proliferation characteristic for HIV-Nef transgenic mice is lymphopenia induced.

The HIV-Nef protein has been implicated in generating high viral loads and T cell activation. Transgenic (tg) mice with constitutive T cell-specific Nef expression show a dramatic reduction in T cell number and highly increased T cell turnover. Previous studies in Nef tg mice attributed this T cell activation to a direct effect of Nef at the cellular level. Given the strongly reduced peripheral...

Lymphopenia-Induced Proliferation Lymphocytes during and after Effects of Increasing IL-7 Availability on